Amorphous Solid Dispersions: Theory and Practice
Amorphous Solid Dispersions: Theory and Practice
This volume offers a comprehensive guide on
the theory and practice of amorphous solid dispersions (ASD) for
handling challenges associated with poorly soluble drugs. In
twenty-three inclusive chapters, the book examines thermodynamics and
kinetics of the amorphous state and amorphous solid dispersions, ASD
technologies, excipients for stabilizing amorphous solid dispersions
such as polymers, and ASD manufacturing technologies, including spray
drying, hot melt extrusion, fluid bed layering and solvent-controlled
micro-precipitation technology (MBP). Each technology is illustrated by
specific case studies. In addition, dedicated sections cover analytical
tools and technologies for characterization of amorphous solid
dispersions, the prediction of long-term stability, and the development
of suitable dissolution methods and regulatory aspects. The book also
highlights future technologies on the horizon, such as supercritical
fluid processing, mesoporous silica, KinetiSol®, and the use of
non-salt-forming organic acids and amino acids for the stabilization of
amorphous systems.
Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.
Ebook format: PDFAmorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.
Ebook page: 702
File size: 15.12 MB
$70.00
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