Heterogeneity in Asthma

Heterogeneity in Asthma

Heterogeneity in Asthma

Heterogeneity in Asthma: 795 (Advances in Experimental Medicine and Biology) by Allan R. Brasier
Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of
vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial
constriction and tissue remodeling.
These signals also are responsible for leukocytic infiltration into the
submucosa, T helper-lymphocyte skewing, and allergic sensitization.
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